htert expression correlates withMYC over-expression in human prostate cancer
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چکیده
منابع مشابه
Combination of metformin and phenformin synergistically inhibits proliferation and hTERT expression in human breast cancer cells
Objective(s): Breast cancer remains a global challenge, and further chemopreventive therapies are still immediately required. Emerging evidence has revealed the potent anti-cancer effects of biguanides, Metformin (MET) and phenformin (PHE). Thus, to explore an efficient chemopreventive strategy for breast cancer, the antiproliferative effects of the combination of MET and PHE against breast can...
متن کاملhTERT mRNA expression correlates with telomerase activity in human breast cancer.
AIMS Telomerase is a ribonucleoprotein enzyme that synthesises telomeres after cell division and maintains chromosomal length and stability thus leading to cellular immortalisation. hTERT (human telomerase reverse transcriptase) gene seems to be the rate-limiting determinant of telomerase reactivation. hTERT mRNA expression was reported to correlate with telomerase activity in cell lines and so...
متن کاملCCR2 expression correlates with prostate cancer progression.
Although the primary role of chemokines and their receptors is controlling the trafficking of leukocytes during inflammatory responses, they also play pleoitropic roles in cancer development. There is emerging evidence that cancer cells produce chemokines that induce tumor cell proliferation or chemotaxis in various cancer types. We have previously reported that MCP-1 acts as a paracrine and au...
متن کاملThe mRNA expression of hTERT in human breast carcinomas correlates with VEGF expression
BACKGROUND: Telomerase is a ribonucleoprotein enzyme that synthesises telomeres after cell division and maintains chromosomal stability leading to cellular immortalisation. hTERT (human telomerase reverse transcriptase) is the rate-limiting determinant of telomerase reactivation. Telomerase has been associated with negative prognostic indicators in some studies. The present study aims to detect...
متن کاملERK 5 Expression in Human Prostate Cancer
The MEK5/ERK5 pathway has recently been implicated in prostate and breast carcinogenesis. Over-expression of MEK5 is associated with aggressive prostate cancer. In this study, we examined the role of ERK5 (a MAPK and specific substrate for MEK5) in prostate cancer. ERK5 immunoreactivity is significantly upregulated in prostate cancer (PC) (n=81) when compared to BPH (n=20) (P<0.0001). Increased...
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ژورنال
عنوان ژورنال: International Journal of Cancer
سال: 2000
ISSN: 0020-7136,1097-0215
DOI: 10.1002/(sici)1097-0215(20000320)89:2<172::aid-ijc12>3.0.co;2-8